- Cleveland Browns select Josh Rosen: QB – UCLA
- New York Giants select Saquon Barkley: RB – Penn State
- New York Jets select Baker Mayfield: QB – Oklahoma
- Buffalo Bills select (trade with Cleveland Browns) Sam Darnold: QB – USC
- Denver Broncos select Quenton Nelson: G – Notre Dame
- Indianapolis Colts select Harold Landry: EDGE – Boston College
- Tampa Bay Buccaneers select Bradley Chubb: EDGE – NCST
- Chicago Bears select Roquan Smith: LB – Georgia
- San Francisco 49ers select Jaire Alexander: CB: Louisville
- Oakland Raiders select Derwin James: S – Florida State
- Miami Dolphins select Rashaan Evans: LB – Alabama
- Cleveland Browns select (trade with Buffalo Bills) Minkah Fitzpatrick: DB – Alabama
- Washington Redskins Denzel Ward: CB – Ohio State
- Baltimore Ravens select (trade with Green Bay Packers) Lamar Jackson: QB: Louisville
- Arizona Cardinals select Calvin Ridley: WR – Alabama
- Green Bay Packers select (trade with Baltimore Ravens) Josh Jackson: CB – Iowa
- Los Angeles Chargers select Tremaine Edmonds: LB – Virginia Tech
- Seattle Seahawks select Will Hernandez: G – UTEP
- Dallas Cowboys select Mike McGlinchey: OT – Notre Dame
- Detroit Lions select Maurice Hurst: DT – Michigan
- Cincinnati Bengals select Connor Williams: T/G – Texas
- Buffalo Bills select Isaiah Wynn: G – Georgia
- New England Patriots select Dallas Goedert: TE – South Dakota State
- Carolina Panthers select De’Ron Payne: DT – Alabama
- Denver Broncos select (trade with Tennessee Titans): Josh Allen: QB – Wyoming
- Atlanta Falcons select Vita Vea: DT – Washington
- New Orleans Saints select D.J. Moore: WR – Maryland
- Pittsburgh Steelers select Josh Sweat: EDGE – Florida State
- Jacksonville Jaguars select Christian Kirk: WR – Texas A&M
- Minnesota Vikings select Leighton Vander Esch: LB – Boise State
- New England Patriots select Marcus Davenport: EDGE – UTSA
- Philadelphia Eagles select Derrius Guice RB – LSU